Disulfiram by Avinash De Sousa

Author:Avinash De Sousa
Language: eng
Format: epub
ISBN: 9789813298767
Publisher: Springer Singapore

4.6 Some Points of Clinical Relevance

1.Currently, there is little direct evidence supporting an effect of disulfiram on relapse prevention, as most clinical trials have focused on its effect on current cocaine use.

2.Future clinical studies include interviews with participants and objective quantifiable measures that can help distinguish between abstinence due to altered drug effects and the effect of environmental triggers.

3.Disulfiram has been used as an alcohol deterrent agent for decades and recent studies indicate that it is also an effective pharmacotherapy for the treatment of cocaine dependence; however, the mechanisms behind its efficacy for alcohol and for cocaine addiction are different. Whereas aldehyde dehydrogenase is the primary target in treating alcoholism, human and preclinical animal studies have indicated that the beneficial effects of disulfiram in cocaine dependence are a result of the inhibition of DBH. The major effect of disulfiram arises via the effect of disulfiram-mediated DBH inhibition on cocaine reward reduction and reducing relapse more so the relapse precipitated by stress.

Download

Copyright Disclaimer:
This site does not store any files on its server. We only index and link to content provided by other sites. Please contact the content providers to delete copyright contents if any and email us, we'll remove relevant links or contents immediately.